Melanoma Research Today is a free monthly online journal that collates and summarizes the latest research about Melanoma, including details on identification, causes, prevention, treatment.

A metastatic melanoma with an unusual immunophenotypic profile.

Gao Z, Stanek A, Chen S

Department of Pathology, Albert Einstein College of Medicine North Shore Long Island Jewish Health System, New Hyde Park, NY 11040, USA.

The most commonly used melanocytic markers are S100, HMB45, Melan-A, or MART-1 and tyrosinase. Melanoma with complete, concordant loss of these markers has not been reported. We report a case of metastatic melanoma with complete loss of staining for S100, HMB45, Melan-A, and tyrosinase. Interestingly, both the primary melanoma and its metastasis were strongly positive for CD99.

Published 6 April 2007 in Am J Dermatopathol, 29(2): 169-71.
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